针刺联合间充质干细胞治疗卒中的研究进展

doi:10.16352/j.issn.1001-6325.2026.10.1419

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (10): 1419-1423.doi: 10.16352/j.issn.1001-6325.2026.10.1419

针刺联合间充质干细胞治疗卒中的研究进展

蔡倩¹, 江天香¹, 潘子欣¹, 甘霖¹, 麻聪聪¹, 林咸明^2*

1.浙江中医药大学第三临床医学院,浙江杭州 310053;
2.浙江中医药大学附属第三医院针灸科,浙江杭州 311500

收稿日期:2025-08-29 修回日期:2025-11-26 出版日期:2026-10-05 发布日期:2026-09-18
通讯作者: ^*linxianming66@126.com
基金资助:
国家自然科学基金(82174502)

Research progress of acupuncture combined with mesenchymal stem cell therapy for stroke

CAI Qian¹, JIANG Tianxiang¹, PAN Zixin¹, GAN Lin¹, MA Congcong¹, LIN Xianming^2*

1. The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053;
2. Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 311500, China

Received:2025-08-29 Revised:2025-11-26 Online:2026-10-05 Published:2026-09-18
Contact: ^*linxianming66@126.com

摘要/Abstract

摘要： 卒中后可导致肢体瘫痪、语言障碍等后遗症,临床相关神经中枢药物治疗难以突破血脑屏障(BBB)递送入脑,对患者的治疗有很大限制。间充质干细胞(MSCs)疗法是目前治疗卒中的新策略,其多能分化潜力和旁分泌能力能促进免疫调节、血管生成和神经回路重建,但在治疗应用之前仍有许多挑战需要克服。针刺可通过抑制炎症反应、激活细胞信号通路、促进神经功能分化等增强MSCs治疗卒中的疗效。本文探讨两者协同作用的分子机制并展望跨学科技术在临床转化中的创新应用。

关键词: 卒中, 针刺, 间充质干细胞, 血脑屏障

Abstract: Stroke can lead to sequelae such as limb paralysis and speech impairment. Clinically, the delivery of relevant neurotropic drugs into the brain is hindered by the blood-brain barrier (BBB), which imposes significant limitations on patient treatment.Mesenchymal stem cells (MSCs) therapy is a new strategy for stroke treatment currently. Its pluripotent differentiation potential and paracrine capabilities can promote immune regulation, angiogenesis, and neural circuit reconstruction. However, many challenges still need to be overcome before its therapeutic application. Acupuncture can enhance the efficacy of MSCs in treating stroke by inhibiting inflammatory responses, activating cell signaling pathways, and promoting neural functional differentiation. This article explores the molecular mechanism of the synergistic effect between the two and discusses the innovative application of interdisciplinary technologies in clinical translation.

Key words: stroke, acupuncture, mesenchymal stem cells, blood-brain barrier

中图分类号:

R246.9

蔡倩, 江天香, 潘子欣, 甘霖, 麻聪聪, 林咸明. 针刺联合间充质干细胞治疗卒中的研究进展[J]. 基础医学与临床, 2026, 46(10): 1419-1423.

CAI Qian, JIANG Tianxiang, PAN Zixin, GAN Lin, MA Congcong, LIN Xianming. Research progress of acupuncture combined with mesenchymal stem cell therapy for stroke[J]. Basic & Clinical Medicine, 2026, 46(10): 1419-1423.

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针刺联合间充质干细胞治疗卒中的研究进展

Research progress of acupuncture combined with mesenchymal stem cell therapy for stroke

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