内源性外泌体调控铁死亡通路在相关疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2026.09.1282

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (9): 1282-1286.doi: 10.16352/j.issn.1001-6325.2026.09.1282

内源性外泌体调控铁死亡通路在相关疾病中的研究进展

郜雪楚^1,2, 韩绍芳², 刘玲英^1,2*

1.内蒙古医科大学基础医学院,内蒙古呼和浩特 010059;
2.中国人民解放军总医院第四医学中心营养科,北京 100037

收稿日期:2025-07-14 修回日期:2025-11-26 出版日期:2026-09-05 发布日期:2026-08-18
通讯作者: ^*liulingyingyisheng@163.com
基金资助:
国家自然科学基金青年项目(81701900);国家卫生健康委医院管理研究所重大课题(SZ2024HL006);中国人民解放军总医院青年自主创新科学基金(22QNCZ031)

Research advances in endogenous exosomes regulating ferroptosis pathways in related diseases

GAO Xuechu^1,2, HAN Shaofang², LIU Lingying^1,2*

1. College of Basic Medicine, Inner Mongolia Medical University, Hohhot 010059;
2. Department of Nutrition, the Fourth Medical Center of the PLA General Hospital, Beijing 100037, China

Received:2025-07-14 Revised:2025-11-26 Online:2026-09-05 Published:2026-08-18
Contact: ^*liulingyingyisheng@163.com

摘要/Abstract

摘要： 铁死亡是一种铁依赖性的新型细胞程序性死亡方式,其核心特征为脂质过氧化与铁离子蓄积导致的抗氧化防御系统失衡。内源性外泌体指生物体内细胞自然分泌的囊泡,通过传递其内容物(母细胞的脂质、蛋白质及核酸物质),在相关疾病,如肝癌、胶质母细胞瘤、胃癌、宫颈癌、小细胞肺癌、食管癌、卵巢癌、心脏疾病、脓毒症相关性脑病、乙型肝炎、呼吸窘迫综合征中通过不同信号通路[Xc^-/GSH/GPX4通路、NAD(P)H/FSP1/CoQ10通路、铁代谢通路、脂质代谢通路]调控铁死亡促病变。深入了解不同疾病状态下,内源性外泌体调控铁死亡的具体分子机制,将为相关疾病的诊疗提供新的靶点与思路。

关键词: 铁死亡, 内源性外泌体, 信号通路, 铁代谢, 脂质代谢

Abstract: Ferroptosis is a novel form of iron-dependent programmed cell death, characterized by lipid peroxidation and iron accumulation which lead to an imbalance in host′s antioxidant defense system. Endogenous exosomes refer to extracellular vesicles secreted by cells within the organism. By transferring their cargo (such as lipids, proteins, and nucleic acids from the parent cells), which regulate ferroptosis through various signaling pathways, including Xc^-/GSH/GPX4 pathway, NAD(P)H/FSP1/CoQ10 pathway, iron metabolism pathway, and lipid metabolism pathway, thereby promotes disease progression in conditions such as hepato-cellular carcinoma, glioblastoma, heart disease, small cell lung cancer, esophageal cancer, ovarian cancer, gastric cancer, cervical cancer,sepsis-associated encephalopathy, hepatitis B and acute respiratory distress syndrome. Research focusing on the specific molecular mechanisms by which endogenous exosomes regulate ferroptosis in different diseases may explore new therapeutic targets and put insights into the diagnosis and treatment of related diseases.

Key words: ferroptosis, endogenous exosome, signaling pathway, iron metabolism pathway, lipid metabolism pathway

中图分类号:

R456

郜雪楚, 韩绍芳, 刘玲英. 内源性外泌体调控铁死亡通路在相关疾病中的研究进展[J]. 基础医学与临床, 2026, 46(9): 1282-1286.

GAO Xuechu, HAN Shaofang, LIU Lingying. Research advances in endogenous exosomes regulating ferroptosis pathways in related diseases[J]. Basic & Clinical Medicine, 2026, 46(9): 1282-1286.

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内源性外泌体调控铁死亡通路在相关疾病中的研究进展

Research advances in endogenous exosomes regulating ferroptosis pathways in related diseases

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