基础医学与临床 ›› 2026, Vol. 46 ›› Issue (10): 1407-1413.doi: 10.16352/j.issn.1001-6325.2026.10.1407

• 临床研究 • 上一篇    下一篇

老年女性口腔衰弱与骨质疏松严重程度的相关性分析

李肖肖, 边立立*, 丁静, 杜雪平   

  1. 首都医科大学附属复兴医院月坛社区卫生服务中心,北京 100045
  • 收稿日期:2026-07-05 修回日期:2026-08-13 出版日期:2026-10-05 发布日期:2026-09-18
  • 通讯作者: *liliweiyu36@ccmu.edu.cn
  • 基金资助:
    首都卫生发展科研专项项目(首发2023-3S-004)

Correlation between oral frailty and severity of osteoporosis in elderly women

LI Xiaoxiao, BIAN Lili*, DING Jing, DU Xueping   

  1. Yuetan Community Health Service Center of Fuxing Hospital, Capital Medical University, Beijing 100045, China
  • Received:2026-07-05 Revised:2026-08-13 Online:2026-10-05 Published:2026-09-18
  • Contact: *liliweiyu36@ccmu.edu.cn

摘要: 目的 探讨老年女性口腔衰弱与骨质疏松严重程度的关系,识别口腔衰弱的骨质疏松风险阈值,为社区协同筛查提供循证依据。方法 采用横断面设计,以方便抽样方法纳入北京市月坛社区卫生服务中心就诊的215例60岁以上女性。以双能X线吸收法测定骨密度,并依据T值分为骨量正常、骨量减少、骨质疏松三级;以口腔衰弱检查表-8(OFI-8)评估口腔功能状态,分为低、中、高风险三组。采用Spearman相关分析、Mantel-Haenszel线性趋势检验,并控制年龄、BMI、月收入等混杂因素,行有序Logistic回归分析。结果 口腔衰弱分组与骨量诊断分组呈低度正相关(r=0.226,P=0.001),存在显著等级趋势(χ2=9.682,P=0.002)。调整混杂因素后,口腔衰弱高风险组(OFI-8≥4分)与骨质疏松严重程度独立相关(OR=2.126,P=0.018),而中风险组无显著关联(OR=0.669,P=0.266),提示≥4分可能为功能损害筛查切点。BMI与骨质疏松严重程度呈独立负向关联(OR=0.892,P=0.005),年龄(OR=1.051,P=0.026)及低收入(OR=3.857,P=0.038)与骨质疏松严重程度呈独立正向关联。平行线检验χ2=9.696,P=0.138,比例优势假设成立。结论 老年女性口腔衰弱与骨质疏松严重程度存在等级相关趋势,OFI-8≥4分可能是骨质疏松高危人群的筛查切点。

关键词: 口腔衰弱, 骨质疏松, 老年女性, 双能X线骨密度检查

Abstract: Objective To investigate the association between oral frailty and the severity of osteoporosis in elderly women, identify the risk threshold of oral frailty for osteoporosis, and provide evidence for joint assessment in patients seeking care at primary healthcare institutions. Methods A cross-sectional study was conducted using convenience sampling. A total of 215 women aged ≥60 years who visited the Yuetan Community health service centers were enrolled. Bone mineral density(BMD) was measured by dual-energy X-ray absorptiometry(DXA),and participants were classified into three groups according to T-scores: normal bone mass,osteopenia,and osteoporosis. Oral frailty was assessed using the Oral Frailty Index-8(OFI-8) and categorized into low-risk(0-2 points),moderate-risk (3 points),and high-risk(≥4 points) groups. Spearman correlation analysis,Mantel-Haenszel linear trend test,and ordinal logistic regression were performed to analyze the association,adjusting for age,BMI,and monthly income. The proportional odds assumption was verified by the parallel lines test prior to regression modeling. Results Oral frailty grouping was positively correlated with BMD diagnostic grouping(r=0.226,P=0.001),and a significant graded association trend was observed(χ2=9.682,P=0.002). After adjusting for confounders,the high-risk oral frailty group(OFI-8 ≥4) was independently associated with greater severity of osteoporosis(OR=2.126, P=0.018),whereas the moderate-risk group showed no significant association(OR=0.669, P=0.266),suggesting that ≥4 points may serve as a screening cutoff for functional impairment.BMI was independently and negatively associated with osteoporosis severity(OR=0.892, P=0.005).Age(OR=1.051, P=0.026) and low income(OR=3.857, P=0.038) were independently and positively associated with osteoporosis severity. The parallel lines test was nonsignificant(χ2=9.696, df=6, P=0.138),confirming that the proportional odds assumption was satisfied. Conclusions Among elderly women visiting primary healthcare institutions,oral frailty demonstrates a graded association trend with osteoporosis severity. An OFI-8 score of ≥4 may be used as a screening cutoff for identifying high-risk populations for osteoporosis.

Key words: oral frailty, osteoporosis, elderly women, dual-energy X-ray absorptiometry

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