氧化应激在急性脑损伤发病机制中的作用

doi:10.16352/j.issn.1001-6325.2026.05.0721

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (5): 721-725.doi: 10.16352/j.issn.1001-6325.2026.05.0721

氧化应激在急性脑损伤发病机制中的作用

刘承国^1*, 李露², 邹川³

成都市第五人民医院 1.急诊科;2.风湿免疫科;3.全科, 四川成都 610000

收稿日期:2025-05-29 修回日期:2025-09-24 出版日期:2026-05-05 发布日期:2026-04-28
通讯作者: ^*763777389@qq.com
基金资助:
四川省医学会青年创新项目(Q2024053)

Role of oxidative stress in the pathogenesis of acute cerebral injury

LIU Chengguo^1*, LI Lu², ZOU Chuan³

1. Department of Emergency Medicine; 2. Department of Rheumatology; 3. Department of General Medicine, Chengdu Fifth People′s Hospital, Chengdu 610000, China

Received:2025-05-29 Revised:2025-09-24 Online:2026-05-05 Published:2026-04-28
Contact: ^*763777389@qq.com

摘要/Abstract

摘要： 急性脑损伤(ACI)包括卒中、创伤性脑损伤等,均以高致残率为特征。氧化应激是其关键病理机制,由线粒体功能障碍和NADPH氧化酶活化导致ROS过度积累,引发脂质过氧化、神经元凋亡及血脑屏障破坏。靶向干预方法如线粒体ROS清除剂(SkQ1)和Nrf2通路激活剂(去铁胺)具有治疗潜力,为ACI提供了新思路。

关键词: 急性脑损伤, 氧化应激, 活性氧(ROS), 靶向治疗

Abstract: Acute cerebral injury (ACI), including stroke and traumatic brain injury, is characterized by high disability. Oxidative stress is the key pathological mechanism, caused by mitochondrial dysfunction and NADPH oxidase activation. This leads to excessive accumulation of ROS, triggering lipid per oxidation, neuronal apoptosis, and blood-brain barrier disruption. Targeting intervention approaches such as mitochondrial ROS scavengers (SkQ1) and Nrf2 pathway activators (desferrioxamine) could have therapeutic potential.

Key words: acute cerebral injury, oxidative stress, reactive oxygen species(ROS), targeting therapy

中图分类号:

R641

刘承国, 李露, 邹川. 氧化应激在急性脑损伤发病机制中的作用[J]. 基础医学与临床, 2026, 46(5): 721-725.

LIU Chengguo, LI Lu, ZOU Chuan. Role of oxidative stress in the pathogenesis of acute cerebral injury[J]. Basic & Clinical Medicine, 2026, 46(5): 721-725.

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氧化应激在急性脑损伤发病机制中的作用

Role of oxidative stress in the pathogenesis of acute cerebral injury

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