创伤性脑损伤患者血栓弹力图参数与血栓调节蛋白的关系

doi:10.16352/j.issn.1001-6325.2026.10.1359

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (10): 1359-1365.doi: 10.16352/j.issn.1001-6325.2026.10.1359

创伤性脑损伤患者血栓弹力图参数与血栓调节蛋白的关系

唐宁健^*, 刘丹, 吴忠俊, 廖冰蓉

电子科技大学医学院附属绵阳医院绵阳市中心医院急诊科,四川绵阳 621000

收稿日期:2025-08-20 修回日期:2025-12-10 出版日期:2026-10-05 发布日期:2026-09-18
通讯作者: ^*37258253@qq.com
基金资助:
四川省卫生健康委员会科研课题(19PJ113)

Correlation of thromboelastography parameters and thrombomodulin levels in patients with traumatic brain injury

TANG Ningjian^*, LIU Dan, WU Zhongjun, LIAO Bingrong

Department of Emergency Medicine, Mianyang Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, Mianyang Central Hospital, Mianyang 621000, China

Received:2025-08-20 Revised:2025-12-10 Online:2026-10-05 Published:2026-09-18
Contact: ^*37258253@qq.com

摘要/Abstract

摘要： 目的探讨创伤性脑损伤(TBI)患者血栓弹力图(TEG)参数变化特征与血栓调节蛋白(TM)水平的关系。方法选取2020年1月至2024年6月收治的179例TBI患者。局部加权回归散点平滑法(LOWESS)分析TM与TEG参数的相关性。多因素Logistic回归分析TBI患者预后不良的因素;广义线性模型及限制性立方样条分析TM与不同严重程度TBI患者预后不良的关系。结果 TM与α角、Ma正相关,与K值、R值负相关(P＜0.05)。α角、Ma、TM、K值、R值升高为TBI患者预后不良的影响因素(P＜0.05)。TM水平在轻、中、重度TBI患者预后不良中呈非线性剂量-反应关系(P_{non-linearity}＜0.05)。K值＜1.05 min时,TM水平与TBI患者预后不良风险的相关性更明显(P_interaction＜0.01)。结论 α角、Ma、TM、K值、R值升高为TBI患者预后不良的影响因素。

关键词: 脑损伤, 创伤性脑损伤, 血栓弹力图, 血栓调节蛋白

Abstract: Objective To explore the relationship between the changes in thromboelastography(TEG) parameters and the levels of thrombomodulin(TM) in patients with traumatic brain injury(TBI). Methods A total of 179 patients with TBI who were admitted from January 2020 to June 2024 were selected. The correlation between TM and TEG parameters was analyzed using the Local Weighted Regression Scatter Smoothing Method(LOWESS). Multivariate Logistic regression was used to analyze the factors associated with poor prognosis in TBI patients; Generalized Linear Model and Restricted Cubic Spline were used to analyze the relationship between TM and poor prognosis in patients with different severity of TBI. Results TM was positively correlated with the α angle and Ma, and negatively correlated with the K value and R value(P＜0.05). The increase in the α angle, Ma, TM, K value, and R value was an influencing factor for the poor prognosis of TBI patients(P＜0.05). The TM level showed a non-linear dose-response relationship in the prognosis of poor outcomes in patients with mild, moderate, and severe TBI(P_{non-linearity}＜0.05). When the K value was less than 1.05 min, the correlation between the TM level and the risk of poor prognosis in TBI patients was more significant(P_interaction＜0.01). Conclusions The increases in α angle, Ma, TM, K value, and R value are factors influencing the poor prognosis of TBI patients.

Key words: brain injury, traumatic brain injury, thromboelastography, thrombomodulin

中图分类号:

唐宁健, 刘丹, 吴忠俊, 廖冰蓉. 创伤性脑损伤患者血栓弹力图参数与血栓调节蛋白的关系[J]. 基础医学与临床, 2026, 46(10): 1359-1365.

TANG Ningjian, LIU Dan, WU Zhongjun, LIAO Bingrong. Correlation of thromboelastography parameters and thrombomodulin levels in patients with traumatic brain injury[J]. Basic & Clinical Medicine, 2026, 46(10): 1359-1365.

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创伤性脑损伤患者血栓弹力图参数与血栓调节蛋白的关系

Correlation of thromboelastography parameters and thrombomodulin levels in patients with traumatic brain injury

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