铜稳态失衡与铜死亡在肺部疾病中的作用

doi:10.16352/j.issn.1001-6325.2026.08.1139

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (8): 1139-1143.doi: 10.16352/j.issn.1001-6325.2026.08.1139

铜稳态失衡与铜死亡在肺部疾病中的作用

李晨¹, 于少飞^2*

1.内蒙古医科大学研究生院,内蒙古呼和浩特 010110;
2.内蒙古自治区人民医院儿科,内蒙古呼和浩特 010020

收稿日期:2025-11-27 修回日期:2026-04-03 发布日期:2026-07-22
通讯作者: ^*yushaofei0707@163.com
基金资助:
内蒙古自治区科技计划(2023YFSH0042)

Roles of copper homeostasis dysregulation and cuproptosis in pulmonary diseases

LI Chen¹, YU Shaofei^2*

1. Graduate School, Inner Mongolia Medical University, Hohhot 010110;
2. Department of Pediatrics, Inner Mongolia Autonomous Region People′s Hospital, Hohhot 010020, China

Received:2025-11-27 Revised:2026-04-03 Published:2026-07-22
Contact: ^*yushaofei0707@163.com

摘要/Abstract

摘要： 铜稳态失衡和铜死亡通过氧化应激和线粒体损伤促进细胞因子的释放,加剧肺部炎性反应;通过参与血管内皮生长因子介导的血管生成,导致慢性阻塞性肺疾病引起的肺动脉高压;通过增强硫氧还蛋白相互作用蛋白信号通路的活性,加重哮喘症状;通过诱导上皮—间充质转化信号通路,诱发肺纤维化;通过上调低氧诱导因子促进血管生成,加速肺部肿瘤的生长和转移。其临床转化研究可为肺部疾病诊疗提供新思路、新方法。

关键词: 铜稳态, 铜死亡, 肺部疾病, 三羧酸循环

Abstract: Copper homeostasis imbalance and cuproptosis exacerbate pulmonary inflammation by promoting the release of cytokines through oxidative stress and mitochondrial damage; contribute to pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD) by participating in vascular endothelial growth factor (VEGF)-mediated angiogenesis; worsen asthma symptoms by enhancing the activity of the thioredoxin-interacting protein (TXNIP) signaling pathway; induce pulmonary fibrosis by activating epithelial-mesenchymal transition (EMT) signaling; and accelerate the growth and metastasis of lung cancer by upregulating hypoxia inducible factor (HIF)-driven angiogenesis. Clinical translation of these mechanisms may provide novel insights and therapeutic strategies for the diagnosis and treatment of pulmonary diseases.

Key words: copper homeostasis, cuproptosis, pulmonary diseases, tricarboxylic acid cycle

中图分类号:

R563

李晨, 于少飞. 铜稳态失衡与铜死亡在肺部疾病中的作用[J]. 基础医学与临床, 2026, 46(8): 1139-1143.

LI Chen, YU Shaofei. Roles of copper homeostasis dysregulation and cuproptosis in pulmonary diseases[J]. Basic & Clinical Medicine, 2026, 46(8): 1139-1143.

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铜稳态失衡与铜死亡在肺部疾病中的作用

Roles of copper homeostasis dysregulation and cuproptosis in pulmonary diseases

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