Research progress on the organ- protective effects of esketamine in the perioperative period

doi:10.16352/j.issn.1001-6325.2026.10.1429

Abstract

Abstract: Esketamine, the dextro-isomer of ketamine, primarily acts as a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Beyond its anesthetic properties, esketamine confers organ protection through multiple mechanisms, including the suppression of inflammatory responses and oxidative stress, regulation of calcium overload, modulation of gut microbiota, control of cellular autophagy, and inhibition of ferroptosis. Consequently, it emerges as a promising therapeutic strategy for mitigating perioperative organ injury.

Key words: esketamine, perioperative period, organ protection

CLC Number:

LU Yapeng, WANG Yingbin, LU Wensheng. Research progress on the organ- protective effects of esketamine in the perioperative period[J]. Basic & Clinical Medicine, 2026, 46(10): 1429-1434.

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