Abstract: Objective To study the expression of CD105 in laryngeal carcinoma and evaluate the clinical significance of microvessel density（MVD）. Methods Pathologic paraffin-embedded sections and clinic data from 40 patients with primary squmamous cell carcinoma of larynx were studied through immunohistochemistry. Microvessel density (MVD) highlighted by CD105 and CD34 were counted according to a standard protocol . Results CD105 expression in tumour tissue was significantly higher than normal health mucosa. The mean CD105-MVD value of T3 and T4 tumours showed a significantly higher staining than T1 and T2；The mean CD105-MVD value of tumours with metastasis was also markedly higher than tumours with no metastasis；The diffenerce of mean CD105-MVD value between in 16 patients with recurred laryngeal carcinoma and in 20 patients with unrecurred laryngeal carcinoma for two years of follow-up was markedly significant（P﹤0.05）. Conclusion CD105 is a marker of tumour angiogenesis and an independent indicator of predicting invasion，metastasis and recurrence , and evaluating prognosis of malignant tumours.

Key words: Laryngeal carcinoma, Angiogenesis, Microvessel density, Metastasis, Recurrence, CD105