Research Progress in Signal Pathway of Corneal Wound Healing in Diabetes Mellitus

Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (3): 326-329.

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Research Progress in Signal Pathway of Corneal Wound Healing in Diabetes Mellitus

Ying ZHANG, Xin-yi WU

Department of Ophthalmology, Qilu Hospital of Shandong University Department of Ophthalmology, Qilu Hospital of Shandong University

Received:2008-05-26 Revised:2008-07-31 Online:2009-03-25 Published:2009-03-25
Contact: Ying ZHANG,

Abstract

Abstract: Delayed wound healing in diabetic cornea may be associated with the activation of MAPK signal pathway, impaired signal transduction of TGF-β signal pathway, abnormal expression of genes related to insulin signal pathway and reduced expression of insulin receptor. In addition, the activation of NF-κb and cytochrome C signal pathway also has harmful influence on delayed wound healing. This paper reviews research progress about signal pathway of delayed wound healing in diabetic cornea.

Key words: Signal pathway, corneal wound healing, diabetes mellitus

Ying ZHANG; Xin-yi WU. Research Progress in Signal Pathway of Corneal Wound Healing in Diabetes Mellitus[J]. Basic & Clinical Medicine, 2009, 29(3): 326-329.

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Research Progress in Signal Pathway of Corneal Wound Healing in Diabetes Mellitus

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