Basic & Clinical Medicine ›› 2026, Vol. 46 ›› Issue (5): 726-729.doi: 10.16352/j.issn.1001-6325.2026.05.0726

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Research advances in endobronchial cryo-denervation for treatment of asthma patients

YUAN Lei*   

  1. Department of Respiratory and Critical Care Medicine, Qingdao University Affiliated Qingdao Municipal Third People′s Hospital, Qingdao 266011, China
  • Received:2025-05-29 Revised:2025-09-24 Online:2026-05-05 Published:2026-04-28
  • Contact: *14570245@qq.com

Abstract: Bronchial cryo-denervation(BCD), an emerging therapeutic intervention for asthma, effectively reduces airway hyper-responsiveness by cryoablating nerve fibers within the bronchial wall. The mechanism of action of BCD, focuses primarily on its effects on airway hyper-responsiveness and airway inflammation. The present article will further summarize and analyze issues identified in clinical practice, while proposing insights and future directions for its application.

Key words: asthma, endobronchial cryo-denervation, airway hyper-responsiveness, cryoablation, neuromodulation

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