Role of oxidative stress in the pathogenesis of acute cerebral injury

doi:10.16352/j.issn.1001-6325.2026.05.0721

Abstract

Abstract: Acute cerebral injury (ACI), including stroke and traumatic brain injury, is characterized by high disability. Oxidative stress is the key pathological mechanism, caused by mitochondrial dysfunction and NADPH oxidase activation. This leads to excessive accumulation of ROS, triggering lipid per oxidation, neuronal apoptosis, and blood-brain barrier disruption. Targeting intervention approaches such as mitochondrial ROS scavengers (SkQ1) and Nrf2 pathway activators (desferrioxamine) could have therapeutic potential.

Key words: acute cerebral injury, oxidative stress, reactive oxygen species(ROS), targeting therapy

CLC Number:

R641

LIU Chengguo, LI Lu, ZOU Chuan. Role of oxidative stress in the pathogenesis of acute cerebral injury[J]. Basic & Clinical Medicine, 2026, 46(5): 721-725.

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