联合检测血清FEIR、LAG-3、KLF5对支原体肺炎患者预后的评估价值

doi:10.16352/j.issn.1001-6325.2026.10.1392

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (10): 1392-1396.doi: 10.16352/j.issn.1001-6325.2026.10.1392

联合检测血清FEIR、LAG-3、KLF5对支原体肺炎患者预后的评估价值

李尼克, 张湘燕^*

贵州医科大学内科学,贵州贵阳 550004

收稿日期:2025-05-29 修回日期:2025-09-24 出版日期:2026-10-05 发布日期:2026-09-18
通讯作者: ^*ovxvge@163.com
基金资助:
国家自然科学基金(8166002)

The assessment value of joint detection of serum FEIR, LAG-3, KLF5 for the prognosis of mycoplasmal pneumonia

LI Nike, ZHANG Xiangyan^*

Department of Internal Medicine, Guizhou Medical University, Guiyang 550004, China

Received:2025-05-29 Revised:2025-09-24 Online:2026-10-05 Published:2026-09-18
Contact: ^*ovxvge@163.com

摘要/Abstract

摘要： 目的联合检测血清免疫黏附抑制因子(FEIR)、淋巴细胞激活基因3(LAG-3)、Kruppel样因子5(KLF5)对支原体肺炎(MPP)患者预后的评估价值。方法选择贵州省人民医院收治的176例MPP患者纳入MPP组,根据病情程度分为重症MPP组(74例)、轻症MPP组(102例)。根据预后情况分为预后良好组(135例)、预后不良组(41例)。另选择176例同期入院体检健康志愿者纳入对照组。ELISA法检测血清FEIR、LAG-3、KLF5水平;多因素Logistic回归分析影响MPP患者预后的因素;ROC曲线分析联合检测血清FEIR、LAG-3、KLF5对MPP患者预后的预测价值。结果与对照组比较,MPP组血清FEIR、LAG-3、KLF5水平显著升高(P＜0.05);与轻症MPP组相比,重症MPP组血清FEIR、LAG-3、KLF5水平进一步升高(P＜0.05);与预后良好组比较,预后不良组C反应蛋白(CRP)、FEIR、LAG-3、KLF5水平均显著升高(P＜0.05);FEIR、LAG-3、KLF5高表达是影响MPP患者预后的独立危险因素(P＜0.05);血清FEIR、LAG-3、KLF5水平单独预测MPP患者预后的AUC分别为0.825、0.810、0.819,3者联合预测的AUC为0.939,优于3者单独预测(Z_{FEIR-三者联合}=3.023、Z_{LAG-3-三者联合}=3.180、Z_{KLF5-三者联合}=3.328,P均＜0.05)。结论 MPP患者血清中FEIR、LAG-3、KLF5表达上调,3者与MPP病情程度密切相关,联合检测对评估MPP患者预后有较高的价值。

关键词: 支原体肺炎, 免疫黏附抑制因子, 淋巴细胞激活基因3, Kruppel样因子5, 预后

Abstract: Objective To assess the value of joint detection of serum immune adhesion inhibitory factor (FEIR), lymphocyte activation gene 3 (LAG-3), and Kruppel like factor 5 (KLF5) in assessing the prognosis of mycoplasmal pneumonia (MPP). Methods A total of 176 MPP patients in Guizhou Provincial People′s Hospital were included in MPP group. Complying with the severity of disease, they were assigned into the severe MPP group (74 cases) and the mild MPP group (102 cases). According to the prognosis, they were included into the good prognosis group(135 cases) and the poor prognosis group (41 cases). Another 176 healthy volunteers who underwent physical check-ups were considered as the control group. ELISA was used to detect serum FEIR, LAG-3, and KLF5. Multivariate logistic regression was performed to analyze the factors affecting the prognosis of MPP. ROC curve was performed to analyze the predictive value of joint detection of serum FEIR, LAG-3, KLF5 for prognosis of MPP. Results Compared with control group, the MPP group had significantly higher serum FEIR, LAG-3, and KLF5 (P＜0.05). Compared with the mild MPP group, the serum levels of FEIR, LAG-3, and KLF5 in the severe MPP group were significantly increased (P＜0.05). Compared with the good prognosis group, the poor prognosis group had significantly higher C-reactive protein (CRP), FEIR, LAG-3, and KLF5 (P＜0.05). High FEIR, LAG-3, and KLF5 were independent risk factors affecting the prognosis of MPP (P＜0.05). The AUC of serum FEIR, LAG-3, and KLF5 alone in predicting the prognosis of MPP was 0.825, 0.810, and 0.819, respectively. The AUC of the joint prediction of the three factors was 0.939, which was better than single prediction of the three factors (Z_FEIR-joint=3.023, Z_LAG-3-joint=3.180, Z_KLF5-joint=3.328, all P＜0.05). Conclusions The FEIR, LAG-3, and KLF5 are upregulated in serum of MPP. The three are closely related to the severity of MPP. Joint detection is of high value in assessing the prognosis of MPP.

Key words: mycoplasmal pneumonia, immune adhesion inhibitory factor, lymphocyte activation gene 3, kruppel like factor 5, prognosis

中图分类号:

R563.1

李尼克, 张湘燕. 联合检测血清FEIR、LAG-3、KLF5对支原体肺炎患者预后的评估价值[J]. 基础医学与临床, 2026, 46(10): 1392-1396.

LI Nike, ZHANG Xiangyan. The assessment value of joint detection of serum FEIR, LAG-3, KLF5 for the prognosis of mycoplasmal pneumonia[J]. Basic & Clinical Medicine, 2026, 46(10): 1392-1396.

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联合检测血清FEIR、LAG-3、KLF5对支原体肺炎患者预后的评估价值

The assessment value of joint detection of serum FEIR, LAG-3, KLF5 for the prognosis of mycoplasmal pneumonia

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