血清RANTES和LTC4对自身免疫性脑炎患者转归的预测价值

doi:10.16352/j.issn.1001-6325.2026.05.0698

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (5): 698-702.doi: 10.16352/j.issn.1001-6325.2026.05.0698

血清RANTES和LTC4对自身免疫性脑炎患者转归的预测价值

彭富治¹, 方芳², 涂鄂文², 陈曦^3*

湖南省第二人民医院(湖南省脑科医院) 1.躯体疾病精神科;2.脑血管病神经内科;3.精神科,湖南长沙 410000

收稿日期:2025-04-23 修回日期:2025-07-14 出版日期:2026-05-05 发布日期:2026-04-28
通讯作者: ^*414476912@qq.com
基金资助:
2025年度湖南省自然科学基金(2025JJ80615)

Predictive value of serum RANTES and LTC4 for outcomes in patients with autoimmune encephalitis

PENG Fuzhi¹, FANG Fang², TU Ewen², CHEN Xi^3*

1. Department of Physical Diseases and Psychiatry; 2. Neurology Department of Cerebrovascular Disease; 3. Department of Psychiatry, the Second People′s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha 410000, China

Received:2025-04-23 Revised:2025-07-14 Online:2026-05-05 Published:2026-04-28
Contact: ^*414476912@qq.com

摘要/Abstract

摘要： 目的探究血清T细胞正常表达和分泌刺激因子(RANTES)、白三烯C4(LTC4)对自身免疫性脑炎(AE)患者疾病转归的预测价值。方法选取2020年8月至2024年8月收治的144例AE患者作为AE组,依据疾病转归情况分为预后良好组(98例)及预后不良组(46例),另选120例病毒性脑炎(VE)患者作为VE组,150例健康体检者作为对照组。用ELISA检测血清CRP、IL-6、TNF-α、RANTES及LTC4水平。比较不同组资料及血清RANTES、LTC4水平。比较不同预后患者资料及血清RANTES、LTC4水平。Pearson法分析RANTES、LTC4水平与CRP、IL-6及TNF-α水平的相关性。多因素Logistic回归分析AE患者预后不良的影响因素。绘制ROC曲线分析血清RANTES、LTC4水平在AE患者预后不良方面的预测价值。结果 AE组、VE组及对照组血清RANTES、LTC4水平依次降低(P＜0.05)。预后不良组患者血清CRP、IL-6、TNF-α、RANTES及LTC4水平高于预后良好组(P＜0.05)。血清RANTES、LTC4水平与CRP、IL-6、TNF-α水平显著正相关(P＜0.05)。血清CRP、IL-6、TNF-α、RANTES、LTC4水平是AE患者预后不良的影响因素(P＜0.05)。血清RANTES、LTC4联合预测AE患者预后不良的价值高于单个指标单独预测(Z_{RANTES-联合}=2.722,P_{RANTES-联合}＜0.01;Z_LTC4-联合=2.343,P_LTC4-联合＜0.05)。结论 AE患者血清RANTES、LTC4水平升高,与患者的疾病转归密切相关,RANTES、LTC4联合预测AE患者预后不良的价值较高。

关键词: 自身免疫性脑炎, T细胞正常表达和分泌刺激因子(RANTES), 白三烯C4, 疾病转归

Abstract: Objective To explore the predictive value of expression and secretion of RANTES(regulated upon activation, normal T cell expressed, and secreted) and leukotriene C4 (LTC4) by peripheral T cells on disease outcomes in patients with autoimmune encephalitis (AE). Methods The patients with AE (144 cases) admitted from August 2020 to August 2024 were selected as the AE group and then were divided into the good prognosis group (98 cases) and the poor prognosis group (46 cases) based on the disease outcomes. Another 120 patients with viral encephalitis (VE) were selected as the VE group, and 150 healthy medical checkup participants were selected as the control group. ELISA was used to detect serum CRP, IL-6, TNF-α, RANTES, and LTC4. The data and serum level of RANTES and LTC4 were compared among different groups. The data and serum RANTES and LTC4 level were compared among patients with different prognoses. Pearson method was used to explore the correlation between RANTES,LTC4 with CRP, IL-6, and TNF-α. Multivariate logistic regression was used to explore the influencing factors of poor prognosis in AE patients. ROC curve was plotted to explore the predictive value of serum RANTES and LTC4 in predicting poor prognosis in AE patients. Results The serum RANTES and LTC4 decreased sequentially in AE group, VE group and in control group (P＜0.05). The poor prognosis group had higher serum level of CRP, IL-6, TNF-α, RANTES, and LTC4 than the good prognosis group (P＜0.05). Serum RANTES and LTC4 were positively correlated with CRP, IL-6, and TNF-α(P＜0.05). Serum CRP, IL-6, TNF-α, RANTES, and LTC4 were influencing factors for poor prognosis in AE patients (P＜0.05). The union of serum RANTES and LTC4 had a higher predictive value for poor prognosis in AE patients than individual predictions(Z_RANTES-union=2.722, P_RANTES-union＜0.01; Z_LTC4-union=2.343, P_LTC4-union＜0.05). Conclusions Serum level of RANTES and LTC4 is elevated in AE patients and closely related to the disease outcomes. The combination of serum level of RANTES and LTC4 has a high value in predicting poor prognosis in AE patients.

Key words: autoimmune encephalitis, regulated upon activation, normal T cell expressed, and secreted(RANTES), leukotriene C4, disease outcomes

中图分类号:

R593.2

彭富治, 方芳, 涂鄂文, 陈曦. 血清RANTES和LTC4对自身免疫性脑炎患者转归的预测价值[J]. 基础医学与临床, 2026, 46(5): 698-702.

PENG Fuzhi, FANG Fang, TU Ewen, CHEN Xi. Predictive value of serum RANTES and LTC4 for outcomes in patients with autoimmune encephalitis[J]. Basic & Clinical Medicine, 2026, 46(5): 698-702.

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血清RANTES和LTC4对自身免疫性脑炎患者转归的预测价值

Predictive value of serum RANTES and LTC4 for outcomes in patients with autoimmune encephalitis

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