中性粒细胞胞外诱捕网在脓毒症相关急性肺损伤中的作用

doi:10.16352/j.issn.1001-6325.2026.04.0597

摘要/Abstract

摘要： 脓毒症是一种由感染后炎性反应引起的临床综合征。中性粒细胞是一种先天免疫细胞,是到达感染/炎性反应部位清除感染和消除炎性反应的先行者。中性粒细胞可以通过释放中性粒细胞胞外陷阱(NETs)来捕获病原微生物,并参与炎性反应和细菌杀灭清除。然而,它们的过度激活会导致体内的炎性反应风暴,进而损害组织并导致器官功能障碍。NETs的适度释放可清除脓毒症相关急性肺损伤中的病原体,但过度生成则导致不可逆组织损伤。控制机体内NETs的释放目前已有GSK199、西维司他、DNase Ⅰ等小分子抑制剂应用于基础实验研究中。

关键词: 中性粒细胞胞外诱捕网, 脓毒症相关急性肺损伤, 炎症, 治疗策略

Abstract: Sepsis is a clinical syndrome caused by inflammatory responses after infection. Neutrophils are a type of innate immune cell and are pioneers in reaching the site of infection and inflammation to clear the infection and eliminate the inflammatory response. Neutrophils can capture pathogenic microorganisms by releasing neutrophil extracellular traps (NETs) and participate in inflammatory responses and bacterial killing and clearance. However, their excessive activation can lead to an inflammatory storm in the body, which in turn damages tissues and causes organ dysfunction. A moderate release of NETs can clear the pathogens in sepsis-induced lung injury, but excessive generation leads to irreversible tissue damage. Currently, small molecule inhibitors such as GSK199, sivelestat and DNase Ⅰ have been applied in basic experimental research to control the release of NETs in the body.

Key words: neutrophil extracellular traps, sepsis-related acute lung injury, inflammation, treatment strategy

中图分类号:

袁策, 叶萃萃, 郭长安, 罗来升, 柳月珍. 中性粒细胞胞外诱捕网在脓毒症相关急性肺损伤中的作用[J]. 基础医学与临床, 2026, 46(4): 597-601.

YUAN Ce, YE Cuicui, GUO Chang′an, LUO Laisheng, LIU Yuezhen. Role of neutrophil extracellular traps in sepsis-related acute lung injury[J]. Basic & Clinical Medicine, 2026, 46(4): 597-601.

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