关键词: 肿瘤, 铁死亡, 铁死亡诱导剂, 抗肿瘤

Abstract: Ferroptosis, which is different from necrosis and apoptosis is a newly discovered programmed cell death. The characteristic of ferroptosis is the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Ferroptosis is involved in the formation and development of different cancers such as hepatocellular cancer, pancreatic cancer, prostate cancer and breast cancer. SLC7A11 and GPX4 are the key regulators in ferroptosis; p53 and BECN1 participate in the ferroptosis via regulating SLC7A11 and GPX4; Inducing ferroptosis might become a new antitumor method in future.

Key words: tumor, ferroptosis, ferroptosis inducer, anticancer