关键词: 一氧化氮, 细胞凋亡, 脑缺血再灌注, 信号通路, s-亚硝基化

Abstract: Nitric oxide level of cerebral tissue was "double peaks-like" during cerebral ischemia-reperfusion, and the role of nitric oxide will change depending on its level in vivo. Nitric oxide mediated apoptosis mainly through four signal pathways. Nitric oxide can make related protein s-nitrosylation via molecular modification, further regulate signal pathways and affect apoptosis.

Key words: Nitric oxide, Apoptosis, Cerebral ischemia-reperfusion, Signal pathway, S-nitrosylation