NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展

doi:10.16352/j.issn.1001-6325.2026.07.1004

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (7): 1004-1008.doi: 10.16352/j.issn.1001-6325.2026.07.1004

NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展

刘翠玲^1,2, 于树娜^1*

1.山东第二医科大学基础医学院人体解剖学教研室,山东潍坊 261053;
2.潍坊护理职业学院医学技术系,山东潍坊 262500

收稿日期:2025-08-04 修回日期:2025-10-30 发布日期:2026-06-23
通讯作者: ^*yushn@sdsmu.edu.cn
基金资助:
山东省医药卫生科技发展计划(202001020642)

Research progress in the role of NLRP3 inflammasome in hepatic ischemia-reperfusion injury

LIU Cuiling^1,2, YU Shuna^1*

1. Department of Human Anatomy, Shandong Second Medical University, Weifang 261053;
2. Department of Medical Technology, Weifang Nursing Vocational College, Weifang 262500, China

Received:2025-08-04 Revised:2025-10-30 Published:2026-06-23
Contact: ^*yushn@sdsmu.edu.cn

摘要/Abstract

摘要： 肝缺血/再灌注损伤(HI/RI)是肝脏外科手术中不可避免的病理生理过程,是导致术后严重并发症发生的重要因素。其机制复杂,涉及氧化应激、细胞内钙过载、炎性反应等多种途径,近年来,NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体作为天然免疫反应的重要调控枢纽,在HI/RI中发挥核心作用。本文旨在系统综述NLRP3炎性小体的结构功能、在HI/RI中的激活机制及其核心作用,并探讨以NLRP3为靶点的多种干预策略的研究现状与挑战,为HI/RI的临床防治提供新的理论视角和策略方向。

关键词: 炎性小体, 肝缺血/再灌注损伤, 细胞焦亡, 炎性反应, 靶向治疗

Abstract: Hepatic ischemia-reperfusion injury (HI/RI) is an inevitable pathophysiological process in liver surgery and is an important factor leading to severe postoperative complications. Its mechanism is complex, involving multiple pathways such as oxidative stress, intracellular calcium overload, and inflammatory response. In recent years, as an important regulatory hub of the innate immune response, the NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome has played a core role in HI/RI. This article reviews the structure and function of the NLRP3 inflammasome, its activation mechanism in HI/RI to identify the core role of this molecule and to explore the research status and challenges of various intervention strategies targeting NLRP3, providing new theoretical perspectives and orientation for clinical prevention and treatment of HI/RI.

Key words: inflammasome, hepatic ischemia-reperfusion injury, pyroptosis, inflammatory response, targeted therapy

中图分类号:

R392

刘翠玲, 于树娜. NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展[J]. 基础医学与临床, 2026, 46(7): 1004-1008.

LIU Cuiling, YU Shuna. Research progress in the role of NLRP3 inflammasome in hepatic ischemia-reperfusion injury[J]. Basic & Clinical Medicine, 2026, 46(7): 1004-1008.

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NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展

Research progress in the role of NLRP3 inflammasome in hepatic ischemia-reperfusion injury

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