嗜铬细胞瘤和副神经节瘤术前准备评估指标的研究进展

doi:10.16352/j.issn.1001-6325.2026.11.1566

摘要/Abstract

摘要： 嗜铬细胞瘤和副神经节瘤(PPGL)是罕见神经内分泌肿瘤,术中血流动力学不稳定(IHI)是PPGL围术期管理的核心挑战。本文系统回顾了当前术前准备的三大评估指标——术前血压、α受体阻滞剂使用时长及临床症状,发现上述指标多反映静态血流动力学状态或间接药理效应,难以全面评估患者的血管反应性及外周灌注,且对IHI的预测价值有限。而外周灌注指数(PPI)作为一种无创、连续的动态灌注监测指标,可通过反映外周血管张力及组织灌注变化,有望为PPGL患者术前准备评估提供补充信息。

关键词: 嗜铬细胞瘤, 副神经节瘤, 血流动力学, 肾上腺素能α受体阻滞剂, 外周灌注指数

Abstract: Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, and intraoperative hemodynamic instability (IHI) represents a major challenge in their perioperative management. This article systematically reviews three routinely used parameters for evaluating preoperative preparation: preoperative blood pressure, duration of α-adrenergic blockade, and clinical symptoms. These parameters primarily reflect static hemodynamic status or indirect pharmacological effects and therefore may not comprehensively characterize vascular reactivity and peripheral perfusion. Moreover, their predictive value for IHI remains limited. As a noninvasive and continuous measure of dynamic perfusion, the peripheral perfusion index (PPI) reflects changes in peripheral vascular tone and tissue perfusion and may provide complementary information for assessing the adequacy of preoperative preparation in patients with PPGL.

Key words: pheochromocytoma, paraganglioma, hemodynamics, α-adrenergic receptor blocker, peripheral perfusion index

中图分类号:

R736.6

韩歌阳, 李宇珂, 韩文聪, 张争, 李楠. 嗜铬细胞瘤和副神经节瘤术前准备评估指标的研究进展[J]. 基础医学与临床, 2026, 46(11): 1566-1572.

HAN Geyang, LI Yuke, HAN Wencong, ZHANG Zheng, LI Nan. Advances in parameters for evaluating preoperative preparation of pheochromocytoma and paraganglioma[J]. Basic & Clinical Medicine, 2026, 46(11): 1566-1572.

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