解偶联蛋白2在肝细胞癌中作用的研究进展

doi:10.16352/j.issn.1001-6325.2026.11.1550

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (11): 1550-1553.doi: 10.16352/j.issn.1001-6325.2026.11.1550

解偶联蛋白2在肝细胞癌中作用的研究进展

孙凤起, 余英杰, 宋运佳, 杨婧, 赵炜明^*

黑龙江中医药大学基础医学院,黑龙江哈尔滨 150040

收稿日期:2025-10-16 修回日期:2026-01-26 出版日期:2026-11-05 发布日期:2026-10-26
通讯作者: ^*zhaowm1969@126.com
基金资助:
黑龙江省卫生健康委科研课题(20250202020514)

Progress of research on the role of uncoupling protein 2 in hepatocellular carcinoma

SUN Fengqi, YU Yingjie, SONG Yunjia, YANG Jing, ZHAO Weiming^*

School of Basic Medicine Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China

Received:2025-10-16 Revised:2026-01-26 Online:2026-11-05 Published:2026-10-26
Contact: ^*zhaowm1969@126.com

摘要/Abstract

摘要： 解偶联蛋白2(UCP2)是线粒体内膜的质子转运蛋白,通过质子漏引发解偶联效应促进肝细胞癌(HCC)的恶性进展。UCP2促进肿瘤细胞代谢重编程,增强糖酵解以满足快速增殖的能量需求;降低线粒体膜电位、减少活性氧,避免肿瘤细胞氧化应激损伤;还能调控凋亡与自噬过程、促进化学治疗耐药等。

关键词: 解偶联蛋白2, 肝细胞癌, 氧化应激

Abstract: Uncoupling protein 2 (UCP2) is a proton transport protein in the inner membrane of mitochondria, which promotes the malignant progression of hepatocellular carcinoma (HCC) by inducing uncoupling effect through proton leakage. UCP2 promotes metabolic reprogramming of tumor cells and enhances glycolysis to meet the energy requirements for rapid proliferation; Reduction of mitochondrial membrane potential may decrease reactive oxygen species and prevent oxidative stress damage to tumor cells; It can also regulate apoptosis and autophagy processes, and promote chemotherapy resistance, and so on.

Key words: uncoupling protein 2, hepatocellular carcinoma, oxidative stress

中图分类号:

R735.7

孙凤起, 余英杰, 宋运佳, 杨婧, 赵炜明. 解偶联蛋白2在肝细胞癌中作用的研究进展[J]. 基础医学与临床, 2026, 46(11): 1550-1553.

SUN Fengqi, YU Yingjie, SONG Yunjia, YANG Jing, ZHAO Weiming. Progress of research on the role of uncoupling protein 2 in hepatocellular carcinoma[J]. Basic & Clinical Medicine, 2026, 46(11): 1550-1553.

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解偶联蛋白2在肝细胞癌中作用的研究进展

Progress of research on the role of uncoupling protein 2 in hepatocellular carcinoma

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