关键词: CD36, 血小板, 单核细胞

Abstract: Objective To use DNA sequencing methods to determine the type II CD36 deficiency genotype, and to analyze the genetic of CD36 gene in guangzhou blood donors. Methods Using PCR-SBT technology to analyze 998 blood donors in guangzhou CD36 genetic coding region; To analyze CD36 protein expression level by flow cytometry instrument. Results In 998 subjects, subject to wild type gene, a single mutation and two mutations was 980, 13 and 5 respectively. Type I CD36 deficiency The type I CD36 deficiency is most commonly detected in subjects who are homozygous or compound heterozygous for mutations. Conclusion Monocyte CD36 protein may be influenced by genetic dose dependent; On the other hand, can be affected by genetic factors besides the encoding gene, resulting in genetic asymmetry in type II CD36 deficiency.

Key words: CD36, platelet, Monocyte