机械敏感离子通道组分1(Piezo1)在衰老及衰老相关疾病中的多维作用

doi:10.16352/j.issn.1001-6325.2026.11.1554

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (11): 1554-1559.doi: 10.16352/j.issn.1001-6325.2026.11.1554

机械敏感离子通道组分1(Piezo1)在衰老及衰老相关疾病中的多维作用

张贝, 刘坤, 侯怡冰, 张恒^*, 朱兵^*

中国中医科学院针灸研究所,北京 100700

收稿日期:2026-05-29 修回日期:2026-09-08 出版日期:2026-11-05 发布日期:2026-10-26
通讯作者: ^*zhangheng08@163.com;zhubing@mail.cintcm.ac.cn
基金资助:
中央级公益性科研院所基本科研业务费专项(ZZCZ2025-025)

Multifaceted role of Piezo-type mechanosensitive ion channel component 1(Piezo1) in aging and age-related diseases

ZHANG Bei, LIU Kun, HOU Yibing, ZHANG Heng^*, ZHU Bing^*

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2026-05-29 Revised:2026-09-08 Online:2026-11-05 Published:2026-10-26
Contact: ^*zhangheng08@163.com;zhubing@mail.cintcm.ac.cn

摘要/Abstract

摘要： 衰老及衰老相关疾病严重影响着全球日益增长的老龄人口的健康,2010年发现的机械敏感离子通道组分1(Piezo1)可以感知组织周围力学环境的变化,在衰老及衰老相关疾病的病理过程中发挥着关键作用。本文综述了Piezo1在衰老及衰老相关疾病中的研究进展,重点从组织层面、细胞层面以及机体营养感知层面探讨了Piezo1参与衰老及衰老相关疾病进程的多维作用机制。简要论述了当前靶向Piezo1从而干预衰老的方案及其优缺点,展望未来结合新兴技术精准解析Piezo1的时空特异性功能,探索更为安全精准的治疗方案,为衰老相关疾病的防治提供更为可靠的证据依据。

Abstract: Aging and age-related diseases have a significant impact on the health of the growing global elderly population. The Piezo-type mechano-sensitive ion channel component 1(Piezo1) senses changes in the mechanical micro-environment of tissues and plays a critical role in the pathological processes of aging and aging-related diseases. This review summarizes recent research progress on Piezo1 in aging and age-related diseases focusing on multi-dimensional mechanisms of action in these processes at the tissue, cellular and whole-organism nutritional sensing level. Also, that briefly summarizes the current approaches to targeting at Piezo1 in aging intervention, to highlight the strengthens and weaknesses. Future perspectives include the use of emerging technologies to precisely elucidate the spatiotemporal roles of Piezo1, with the aim of exploring safer and more accurate therapeutic strategies and solid evidence for management of aging-associated disorders.

Key words: aging, age-related disease, Piezo-type mechanic-sensitive ion channel component 1(Piezo1), age-related change, cellular dysfunction

中图分类号:

R339.38

张贝, 刘坤, 侯怡冰, 张恒, 朱兵. 机械敏感离子通道组分1(Piezo1)在衰老及衰老相关疾病中的多维作用[J]. 基础医学与临床, 2026, 46(11): 1554-1559.

ZHANG Bei, LIU Kun, HOU Yibing, ZHANG Heng, ZHU Bing. Multifaceted role of Piezo-type mechanosensitive ion channel component 1(Piezo1) in aging and age-related diseases[J]. Basic & Clinical Medicine, 2026, 46(11): 1554-1559.

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机械敏感离子通道组分1(Piezo1)在衰老及衰老相关疾病中的多维作用

Multifaceted role of Piezo-type mechanosensitive ion channel component 1(Piezo1) in aging and age-related diseases

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