The progress on the pathogenesis of autoimmune hepatitis

doi:10.16352/j.issn.1001-6325.2026.08.1135

Abstract

Abstract: Autoimmune hepatitis (AIH) is a chronic, inflammatory liver disease mediated by the immune system. Due to a breakdown in immune tolerance to liver autoantigens, multiple immune cells become activated and release abundant inflammatory factors. These autoantigens and inflammatory factors act upon cell surface receptors, activating multiple signaling pathways, including NF-κB, AMPK, PI3K/Akt, JAK/STAT, and MAPK, which induce or exacerbate immune-mediated liver injury. This occurs through the modulation of various processes in immune cells (such as dendritic cells, macrophages, and T cells), including energy metabolism, autophagy, apoptosis, and receptor expression.

Key words: autoimmune hepatitis, immune mechanism, signaling pathway

CLC Number:

R575

WANG Qianchen, WAN Peng, REN Xinyao, WANG Yangyang. The progress on the pathogenesis of autoimmune hepatitis[J]. Basic & Clinical Medicine, 2026, 46(8): 1135-1138.

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