Mechanism of irisin effect in type 2 diabetes mellitus and chronic heart failure

doi:10.16352/j.issn.1001-6325.2026.07.1014

Abstract

Abstract: Type 2 diabetes mellitus(T2DM) is closely related to chronic heart failure in the view point of patho-physiological mechanism. Research has shown that irisin as a muscle factor induced by exercise, is widely distributed in human body, which may improve blood glucose threshold of T2DM through a mechanism of reducing insulin resistance, regulating glucose and lipid metabolism, protecting beta cell function, and enhancing cardiac stem cell proliferation and angiogenesis, improving cardiac pathological remodeling, reducing cell apoptosis and so to protect and improve cardiac function.

Key words: irisin, type 2 diabetes mellitus, chronic heart failure

CLC Number:

YANG Xue, CHENG Xiaoliang. Mechanism of irisin effect in type 2 diabetes mellitus and chronic heart failure[J]. Basic & Clinical Medicine, 2026, 46(7): 1014-1018.

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