Multifaceted role of Piezo-type mechanosensitive ion channel component 1(Piezo1) in aging and age-related diseases

doi:10.16352/j.issn.1001-6325.2026.11.1554

Abstract

Abstract: Aging and age-related diseases have a significant impact on the health of the growing global elderly population. The Piezo-type mechano-sensitive ion channel component 1(Piezo1) senses changes in the mechanical micro-environment of tissues and plays a critical role in the pathological processes of aging and aging-related diseases. This review summarizes recent research progress on Piezo1 in aging and age-related diseases focusing on multi-dimensional mechanisms of action in these processes at the tissue, cellular and whole-organism nutritional sensing level. Also, that briefly summarizes the current approaches to targeting at Piezo1 in aging intervention, to highlight the strengthens and weaknesses. Future perspectives include the use of emerging technologies to precisely elucidate the spatiotemporal roles of Piezo1, with the aim of exploring safer and more accurate therapeutic strategies and solid evidence for management of aging-associated disorders.

Key words: aging, age-related disease, Piezo-type mechanic-sensitive ion channel component 1(Piezo1), age-related change, cellular dysfunction

CLC Number:

R339.38

ZHANG Bei, LIU Kun, HOU Yibing, ZHANG Heng, ZHU Bing. Multifaceted role of Piezo-type mechanosensitive ion channel component 1(Piezo1) in aging and age-related diseases[J]. Basic & Clinical Medicine, 2026, 46(11): 1554-1559.

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