The assessment value of joint detection of serum FEIR, LAG-3, KLF5 for the prognosis of mycoplasmal pneumonia

doi:10.16352/j.issn.1001-6325.2026.10.1392

Abstract

Abstract: Objective To assess the value of joint detection of serum immune adhesion inhibitory factor (FEIR), lymphocyte activation gene 3 (LAG-3), and Kruppel like factor 5 (KLF5) in assessing the prognosis of mycoplasmal pneumonia (MPP). Methods A total of 176 MPP patients in Guizhou Provincial People′s Hospital were included in MPP group. Complying with the severity of disease, they were assigned into the severe MPP group (74 cases) and the mild MPP group (102 cases). According to the prognosis, they were included into the good prognosis group(135 cases) and the poor prognosis group (41 cases). Another 176 healthy volunteers who underwent physical check-ups were considered as the control group. ELISA was used to detect serum FEIR, LAG-3, and KLF5. Multivariate logistic regression was performed to analyze the factors affecting the prognosis of MPP. ROC curve was performed to analyze the predictive value of joint detection of serum FEIR, LAG-3, KLF5 for prognosis of MPP. Results Compared with control group, the MPP group had significantly higher serum FEIR, LAG-3, and KLF5 (P＜0.05). Compared with the mild MPP group, the serum levels of FEIR, LAG-3, and KLF5 in the severe MPP group were significantly increased (P＜0.05). Compared with the good prognosis group, the poor prognosis group had significantly higher C-reactive protein (CRP), FEIR, LAG-3, and KLF5 (P＜0.05). High FEIR, LAG-3, and KLF5 were independent risk factors affecting the prognosis of MPP (P＜0.05). The AUC of serum FEIR, LAG-3, and KLF5 alone in predicting the prognosis of MPP was 0.825, 0.810, and 0.819, respectively. The AUC of the joint prediction of the three factors was 0.939, which was better than single prediction of the three factors (Z_FEIR-joint=3.023, Z_LAG-3-joint=3.180, Z_KLF5-joint=3.328, all P＜0.05). Conclusions The FEIR, LAG-3, and KLF5 are upregulated in serum of MPP. The three are closely related to the severity of MPP. Joint detection is of high value in assessing the prognosis of MPP.

Key words: mycoplasmal pneumonia, immune adhesion inhibitory factor, lymphocyte activation gene 3, kruppel like factor 5, prognosis

CLC Number:

R563.1

LI Nike, ZHANG Xiangyan. The assessment value of joint detection of serum FEIR, LAG-3, KLF5 for the prognosis of mycoplasmal pneumonia[J]. Basic & Clinical Medicine, 2026, 46(10): 1392-1396.

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