Abstract: Circular RNA (circRNA) is a unique endogenous non-coding RNA. Most circRNAs are conserved within the organism and often show specific expression at the stage of tissue development. Circular RNA plays a key role in the regulation of tumorigenesis and development. Therefore, circRNA is one of the hot spots for the study of digestive system, gynecological and other cancer diseases, and it is found that it can be used as a new tumor marker and may become a new target for clinical treatment.

Key words: Cyclic RNA, Non-coding RNA, Gene expression regulation, Leukemia