Abstract: Objective The study on the effect of cardiac remodeling induced by low level adiponectin（APN）and insulin resistance(IR). Methods 16 wild-type C57 mice were randomly divided into control and IR groups.16 APN gene knockout mice were randomly divided into APNKO and APNKO+IR groups. The IR and APNKO+IR groups were a high-fat feed to induce insulin resistance.After 12 weeks,cholesterol(TC)，triglycerides(TG)，fasting plasma glucose(FPG), fasting insulin(FINS) were measured.HOMA-IR,HWI and LVWI were calculated.The left ventricular myocardial were dyed by Masson staining to observe the degree of myocardial fibrosis,and the protein expression of matrix metalloproteinase-9(MMP-9) and APN in myocardial were detected with western blot. Results Low level APN and IR increased heart weight, left ventricular weight, HWI, LVWI（P<0.05）.There were interaction between IR and low level APN on the TC，TG, FPG, FINS, and the index related myocardial fibrosis（P<0.05）, and they were positive effect. There was also interaction effect between IR and low level APN on myocardial APN expression, but it was the negative effects （P<0.05）.Conclusions Both low level adiponectin and insulin resistance could lead to cardiac remodeling synergistically.

Key words: insulin resistance, adiponectin, cardiac remodeling