Abstract: Phosphatase and tensin homologue deleted on chromosome 10（PTEN）is a protein contains lipid and protein phosphatase activity. The activation of PTEN and increased mitochondria or nuclear translocation after ischemia-anoxia in brain may determin the fate of neurons. Therefore, elucidation the molecular mechanisms of subcellular localization of PTEN after ischemia-anoxia would provide new insights in the target therapy of a large number of acute/chronic neurodegenerative disorders and drug design.

Key words: PTEN, ischemia, anoxia, neuron, subcellular localization