Abstract: Abstract: Objective To investigate the relationship between Livin and leukemia multi-drug resistance, and study its effect on leukemia multi-drug resistance. Methods　The expressions of Livin in leukemia cell line THP-1 and leukemia multi-drug resistance cell line THP-1R were detected by RT-PCR and Western blot. The siRNA of Livin was transfected by RNAi-Mate into THP-1R, the expression of Livin was detected by RT-PCR and Western blot, The resistance index was detected by MTT. Results　The expression of Livin in THP-1R was higher than that of THP-1 (P<0.05). After transfected with the siRNA of Livin, the resistance index was decreased significantly, and the expression of Livin was decreased compared with untransfected cells (P< 0.05). Conclusion　The high-level expression of Livin may be one of the mechanisms of leukemia multi-drug resistance.

Key words: Key words: Livin, Leukemia, Multi-drug resistance