Abstract: Abstract： Hypoxia has been implicated in the pathogenesis of cardiovascular diseases, respiratory diseases and tumors that results in heart rate variability (HRV) changes. The change of HRV is related to a lot of diseases, so HRV is often used in clinic as an important index to predict or evaluate diseases. The newly clinical application of HRV and research progress of hypoxia on HRV are reviewed briefly.

Key words: Key words: HRV, heart, ANS, hypoxia