Abstract: Chronic Obstructive Pulmonary Disease（COPD）is a common disease, the characteristic of which is airflow limitation and airway remodeling, thus worsening the structure and function of the lung. COPD is not only implicated in the lung, but involve in some other extrapulumonary effects, also called systemic effects, through the systemic inflammation caused by the activation of inflammation mediators. The most frequent systemic effects are: skeletal muscle wasting, cachexia, osteoporosis, etc. And the prevalences of ischemic heart disease, pulmonary hypertension, diabetes mellitus are higher in COPD patients because of the chronic inflammation.

Key words: Chronic Obstructive Pulmonary Disease, inflammation, skeletal muscle wasting, osteoporosis, pulmonary hypertension, diabetes mellitus