Abstract: Objective To investigate the TGF-β1 expression and the effects of sodium ferulate in rats' myocardium necrosis model. Methods Rat myocardium necrosis model was induced by Isoproterenol (15mg/kg). The rats were injected SF to carry out intervention studies after stable 2 days. TGF-β1 protein and mRNA expression in myocardium were detected by immunohistochemistry and RT-PCR. Results TGF-β1 mRNA expression increased obviously as compared with control group at 24 h（P <0.05）and decreased gradually at 48 h. TGF-β1 protein expression increased to follow the severity. TGF-β1 mRNA expression decreased gradually by injection SF later, its protein expression was also improving. Conclusion SF could inhibit TGF-β1 expression in MF.

Key words: Myocardial fibrosis, TGF-β1, SF, Animal model