Abstract: The Hippo kinase pathway is a newly described growth regulatory pathway and restricts both cell growth and proliferation, as well as to induce apoptosis, the inactivation or deregulation of the pathway might be particularly advantageous to cancer cells. Several tumor suppressor genes and one candidate oncogene have been implicated as members of this pathway, YAP is a candidate oncogene, which is observed to overexpress in several human cancers, and RASSF or MER functions as tumour suppressor gene and loss-of-function mutation of them has been observed in several human cancer cell lines.

Key words: Hippo signaling, tumor suppressor gene, oncogene, cancer