Abstract: The regulation of food intake is complex and involves many peripheral peptides. The short-term signals include satiety signals and hunger signals generated by gastrointestinal tract. The long-term signals mainly include adiposity signals produced by adipose tissue. In this paper, we review the effects of cholecystokinin, Glucagon-like peptide 1, peptide YY, pancreatic polypeptide, oxyntomodulin，ghrelin, leptin and insulin on appetite and body weight control, and their roles in obese treatment.

Key words: food intake, peptide, obese