Progress in research on the role of heme oxygenase - 1 in cardiovascular diseases

Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (9): 999-1001.

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Progress in research on the role of heme oxygenase - 1 in cardiovascular diseases

Ting-ting LI, Yuan GUO

Qilu Hospital of Shandong University Qilu Hospital of Shandong University

Received:2008-12-18 Revised:2009-02-21 Online:2009-09-20 Published:2009-09-20
Contact: Yuan GUO

Abstract

Abstract: Heme oxygenase-1 (HO-1) is an inducible stress protein. In addition to its role in heme degradation, several positive biological effects exerted by this enzyme have gained attention, as anti-in?ammatory, anti-apoptotic, anti-proliferative and cytoprotective functions. This oxidase system with wide function takes part in the pathophysiology of cardiovascular system. It is related to multiple cardiovascular diseases including hypertension, atherosclerosis, ischemia /reperfusion injury and postangioplasty restenosis.

Key words: heme oxygenase-1, carbon monoxide, bilirubin, hypertension, atherosclerosis

Ting-ting LI; Yuan GUO. Progress in research on the role of heme oxygenase - 1 in cardiovascular diseases[J]. Basic & Clinical Medicine, 2009, 29(9): 999-1001.

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Progress in research on the role of heme oxygenase - 1 in cardiovascular diseases

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