Abstract: PTEN (Phosphatase and Tensin Homology deleted from Chromosome ten)，a putative antioncogene,encodes a PTEN protein that has a dual specificity phosphatase activity with both protein phosphatase and lipid phosphatase，which is capable of regulating lots of molecules through inhibiting the PI3K/Akt signaling pathway.Recently，some scholars dedicate to the modulation of PTEN，which demonstrates that PTEN can be regulated by multiple factors in the level of gene and protein.This review briefly summarizes current knowledge about the modulation of PTEN and its mechanisms.

Key words: PTEN, Regulate, Mechanism