Abstract: Objective:To identify the effects of androgen on mouse model of autoimmune ovary failure. Methods: Fifty mice were chosen and randomly divided into five groups of ten, that were the control group, early therapeutic group and model group, late therapeutic group and model group. Autoimmune POF was induced in forty mouse by Pzp3. Then, animals were randomly divided into four groups of ten; two of the groups were treated with androgen from the 15th and 20th day after immune. The control group was treated with distilled water. The therapeutic efficacy of each treatment was evaluated by observing and measuring the changes in sexual cycles of mice, the serum level of AzpAb, infiltration of cells positively expressing CD45 in the ovary as well as the percentage of growing follicles of the ovary. Results: The sexual cycles, serum level of AzpAb, infiltration of cells positively expressing CD45 in the ovary of each model group was higher than control group; early therapeutic group was lower than model group; and serum level of AzpAb in early therapeutic group was lower than late therapeutic group. The percentage of growing follicles in the ovary of each model group was lower than control group; early therapeutic group was higher than model group and late therapeutic group. Conclusion: The use of androgen in mice with autoimmune POF could notably ameliorate the pathogenetic conditions of the disorder, and the treatment during prophase was apparently more effective than during the advanced stage.

Key words: androgen, premature ovary failure, autoimmune, therapy