Abstract: Objective To investigate the associated mechanism of gastroparesis in Diabetic Rats. Methods SD rats were randomly divided into control group and diabetic group. 10 weeks later, gastroparesis model was detected. The apoptosis rate and mitochondrial membrane potential of the gastric smooth muscle cells were detected by flow cytometry.Cytochrome C was detected by immunohistochemistry. Results Compared with rats in control group: ①Typical symptoms of diabetes mellitus appeared; The rate of gastric residual pigment was significantly higher（P＜0.01）. ②Apoptosis rate was significantly higher（P＜0.01）; Mitochondrial membrane potential was significantly lower（P＜0.01）; Cytochrome C was significantly higher（P＜0.05）. Conclusions Mitochondrion contributes to smooth muscle cell apoptosis ,which paly a partial role in diabetic gastroparesis.

Key words: Diabetes, Gastroparesis, Apoptosis, Mitochondrial membrane potential