Abstract: Focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase, is at the cross of the numerous intra-cellular signal transduction. The activated FAK has been implicated in a diverse array of cellular behavious. Advanced relevant observations of FAK and fibrosis show that FAK plays an important role in fibrosis disease, the targeting of FAK may represents a novel therapeutic strategy.

Key words: focal adhesion kinase, fibrosis