Advance on iron overload in liver diseases

doi:10.16352/j.issn.1001-6325.2023.06.0990

Abstract

Abstract: Iron is essential for living organisms. Iron-containing proteins play a key role in cell function, while iron overload produces reactive oxygen species through electron transfer, resulting in DNA damage, oxidative stress, metabolic disorder and tissue as well as organ dysfunction. Liver is the main organ of iron storage and is related to regulating the metabolism, utilization and excretion of iron and maintaining iron homeostasis. Iron overload is common in patients with liver diseases, which is closely related to the occurrence and development of liver diseases.

Key words: iron overload, iron metabolism, liver disease, mechanism research

CLC Number:

R363

LIU Lei, DING Lan, YUAN Yuan, YE Jing. Advance on iron overload in liver diseases[J]. Basic & Clinical Medicine, 2023, 43(6): 990-993.

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