鸢尾素在2型糖尿病及慢性心力衰竭中的作用机制

doi:10.16352/j.issn.1001-6325.2026.07.1014

摘要/Abstract

摘要： 2型糖尿病(T2DM)和慢性心力衰竭之间存在着密切的病理生理联系。鸢尾素(irisin)作为一种由运动诱导的肌肉因子,在人体内分布广泛,存在着多重生物学功能。研究表明,鸢尾素通过改善胰岛素抵抗、调节糖脂代谢、保护β细胞功能等途径改善T2DM的血糖阈值,并增强心脏干细胞增殖及新生血管生成、改善心脏病理性重构、减少细胞凋亡等机制改善心功能。

关键词: 鸢尾素, 2型糖尿病, 慢性心力衰竭

Abstract: Type 2 diabetes mellitus(T2DM) is closely related to chronic heart failure in the view point of patho-physiological mechanism. Research has shown that irisin as a muscle factor induced by exercise, is widely distributed in human body, which may improve blood glucose threshold of T2DM through a mechanism of reducing insulin resistance, regulating glucose and lipid metabolism, protecting beta cell function, and enhancing cardiac stem cell proliferation and angiogenesis, improving cardiac pathological remodeling, reducing cell apoptosis and so to protect and improve cardiac function.

Key words: irisin, type 2 diabetes mellitus, chronic heart failure

中图分类号:

杨雪, 程晓亮. 鸢尾素在2型糖尿病及慢性心力衰竭中的作用机制[J]. 基础医学与临床, 2026, 46(7): 1014-1018.

YANG Xue, CHENG Xiaoliang. Mechanism of irisin effect in type 2 diabetes mellitus and chronic heart failure[J]. Basic & Clinical Medicine, 2026, 46(7): 1014-1018.

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