Abstract: Parkinson's disease (PD) is a common neurodegenerative disease in the central neural system. Genetic and environmental factors induce microglia secrete more interleukin-1, which will cause dopaminergic neurons death through several mechanisms, such as promoting the synthesis of other pro-inflammatory cytokines, producing free radicals, increasing the intracellular calcium concentration, and inducing elevation of α-synuclein , and so on. It is a potential therapeutic target for Parkinson's disease.

Key words: interleukin-1, Parkinson’s disease, pathogenesis