Research advances in endogenous exosomes regulating ferroptosis pathways in related diseases

doi:10.16352/j.issn.1001-6325.2026.09.1282

Abstract

Abstract: Ferroptosis is a novel form of iron-dependent programmed cell death, characterized by lipid peroxidation and iron accumulation which lead to an imbalance in host′s antioxidant defense system. Endogenous exosomes refer to extracellular vesicles secreted by cells within the organism. By transferring their cargo (such as lipids, proteins, and nucleic acids from the parent cells), which regulate ferroptosis through various signaling pathways, including Xc^-/GSH/GPX4 pathway, NAD(P)H/FSP1/CoQ10 pathway, iron metabolism pathway, and lipid metabolism pathway, thereby promotes disease progression in conditions such as hepato-cellular carcinoma, glioblastoma, heart disease, small cell lung cancer, esophageal cancer, ovarian cancer, gastric cancer, cervical cancer,sepsis-associated encephalopathy, hepatitis B and acute respiratory distress syndrome. Research focusing on the specific molecular mechanisms by which endogenous exosomes regulate ferroptosis in different diseases may explore new therapeutic targets and put insights into the diagnosis and treatment of related diseases.

Key words: ferroptosis, endogenous exosome, signaling pathway, iron metabolism pathway, lipid metabolism pathway

CLC Number:

R456

GAO Xuechu, HAN Shaofang, LIU Lingying. Research advances in endogenous exosomes regulating ferroptosis pathways in related diseases[J]. Basic & Clinical Medicine, 2026, 46(9): 1282-1286.

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