Advances in DNA-mediated cell membrane engineering

doi:10.16352/j.issn.1001-6325.2026.06.0872

Abstract

Abstract: Cell membrane engineering is a key technology for endowing cells with novel recognition, response, and regulatory functions, which holds significant value for the advancement of cell therapy and precision medicine. DNA nanotechnology exhibits unique advantages in the precise functionalization of cell membranes owing to its excellent programmability, addressability, and biocompatibility. This article reviews the latest advances in cell membrane engineering based on oligonucleotides, focusing on two major strategies: chemical covalent modification and noncovalent binding. The modification mechanisms, technical characteristics, and application status of these methods in cell therapy are systematically elaborated. Finally, representative strategies for DNA-mediated cell membrane modification are summarized, and the development prospects in the fields of cell engineering and precision medicine are discussed.

Key words: oligonucleotides, cell surface modification, DNA nanotechnology, precision medicine

CLC Number:

R318.08

ZHANG Yi¹, LIAO Miqi², LANG Mingfei^1*. Advances in DNA-mediated cell membrane engineering[J]. Basic & Clinical Medicine, 2026, 46(6): 872-876.

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