Advances in hydrogen sulfide therapy for acute lung injury

doi:10.16352/j.issn.1001-6325.2026.04.0592

Abstract

Abstract: Hydrogen sulfide (H₂S), as a gaseous signaling molecule, can significantly alleviate acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and delay disease progression. H₂S exerts its effects by suppressing the release of pro-inflammatory factors and reducing oxidative stress through its anti-inflammatory and antioxidant properties; it mitigates lung tissue damage by regulating various forms of cell death, including apoptosis, autophagy, pyroptosis, and ferroptosis; and it maintains the integrity of the pulmonary vascular endothelial barrier, thereby reducing pulmonary edema. Additionally, H₂S can modulate the activity of related proteins via sulfhydration, contributing to its lung-protective effects.

Key words: hydrogen sulfide, pneumonia, sepsis, acute lung injury

CLC Number:

R563

ZHU Min, TANG Miaomiao. Advances in hydrogen sulfide therapy for acute lung injury[J]. Basic & Clinical Medicine, 2026, 46(4): 592-596.

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