Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (9): 1122-1131.doi: 10.16352/j.issn.1001-6325.2025.09.1122
Special Issue: 双语出版 ; Bilingual Channel
Previous Articles Next Articles
WANG Qiumei1#, LI Xiaoyuan2#, KANG Lin1, SUN Xiaohong1, LI Hailong3, DUAN Yanping4, LIU Ying5, GUAN Mei2*, ZHAO Lin2*
Received:2025-04-14
Revised:2025-07-07
Online:2025-09-05
Published:2025-08-27
Contact:
*guanmei@pumch.cn;zhaolin4412@pumch.cn
CLC Number:
WANG Qiumei, LI Xiaoyuan, KANG Lin, SUN Xiaohong, LI Hailong, DUAN Yanping, LIU Ying, GUAN Mei, ZHAO Lin. Consensus recommendation on Comprehensive Geriatric Assessment for elderly cancer patients from Peking Union Medical College Hospital[J]. Basic & Clinical Medicine, 2025, 45(9): 1122-1131.
| [1] | Han BF,Zheng RS,Zeng HM,et al.Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent,2024, 4:47-53.doi:10.1016/j.jncc.2024.01.006.eCollection 2024 Mar. |
| [2] | 陈旭娇,严静,王建业,等.老年综合评估技术应用中国专家共识[J].中华老年医学杂志,2017, 36:471-477. |
| [3] | Corre R, Greillier L, Le Caër H, et al. Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non-small-cell lung cancer: the phase III randomized ESOGIA GFPC-GECP 08-02 study[J]. J Clin Oncol, 2016, 34: 1476-1483. doi:10.1200/JCO.2015.63.5839. |
| [4] | Hamaker ME, Seynaeve C, Wymenga AN, et al. Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: results from the OMEGA study of the Dutch breast cancer trialists′ group[J]. Breast, 2014, 23: 81-87. doi:10.1016/j.breast.2013.11.004. |
| [5] | Anwar MR,Yeretzian ST, Ayala AP,et al.Effectiveness of geriatric assessment and management in older cancer patients: a systematic review and meta-analysis[J].J Natl Cancer Inst,2023,115:1483-1496. doi:10.1093/jnci/djad200. |
| [6] | Cesari M,Araujo DC, Amuthavalli T,et al. Evidence for the domains supporting the construct of intrinsic capacity[J].J Gerontol A Biol Sci Med Sci, 2018,73:1653-1660. doi:10.1093/gerona/gly011. |
| [7] | Veronese N, Custodero C, Cella A,et al.Prevalence of multidimensional frailty and pre-frailty in older people in different settings[J].Ageing Res Rev,2021,72:101498.doi:10.1016/j.arr.2021.101498.Epub 2021 Oct 23. |
| [8] | Ditzel HM, Giger AW, Lund CM, et al. Association between Geriatric 8 frailty and health-related quality of life in older patients with cancer (PROGNOSIS-G8): a Danish single-centre, prospective cohort study[J]. Lancet Healthy Longev, 2024,5:100612. doi:10.1016/S2666-7568(24)00118-1. Epub 2024 Aug 29. |
| [9] | Handforth C, Clegg A, Young C, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review[J]. Ann Oncol,2015,26:1091-1101. doi:10.1093/annonc/mdu540. |
| [10] | Ethun CG, Bilen MA, Jani AB,et al.Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology[J]. CA Cancer J Clin, 2017,67:362-377. doi:10.3322/caac.21406. |
| [11] | Jespersen E, Winther SB, Minet LR,et al. Shorter overall survival in older patients with gastrointestinal cancer receiving palliative chemotherapy-a prospective, clinical study[J]. J Geriatr Oncol, 2021,12:578-584. doi:10.1016/j.jgo.2020.10.007. |
| [12] | Narasimhulu DM, McGree ME, Weaver AL, et al. Frailty is a determinant of suboptimal chemotherapy in women with advanced ovarian cancer[J]. Gynecol Oncol, 2020,158:646-652. doi:10.1016/j.ygyno.2020.05.04612. |
| [13] | Ribeiro AR, Howlett SE, Fernandes A. Frailty-A promising concept to evaluate disease vulnerability[J]. Mech Ageing Dev, 2020,187:111217. doi:10.1016/j.mad.2020.111217. |
| [14] | Shaw JF, Budiansky D, Sharif F, et al. The association of frailty with outcomes after cancer surgery: a systematic review and metaanalysis[J]. Ann Surg Oncol, 2022,29:4690-4704. doi:10.1245/s10434-021-11321-2. |
| [15] | International Society of Geriatrie Oncology (SIOG). Comprehensive geriatric assessment. Available from: https://siog.org/resources/resources-siog/comprehensive-geriatric-assessment/. Accessed November 6, 2022. |
| [16] | Wildiers H, Heeren P, Puts M, et al. International society of geriatric oncology consensus on geriatric assessment in older patients with cancer[J]. J Clin Oncol, 2014,32:2595-2603. doi:10.1200/JCO.2013.54.8347. |
| [17] | Mohile SG, Dale W, Somerfield MR, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology[J]. J Clin Oncol, 2018,36:2326-2347. doi:10.1200/JCO.2018.78.8687. |
| [18] | Goede V.Frailty and cancer: current perspectives on assessment and monitoring[J].Clin Interv Aging, 2023,18:505-521. doi:10.2147/CIA.S365494. eCollection 2023. |
| [19] | Garcia MV, Agar MR, Soo WK, et al. Screening tools for identifying older adults with cancer who may benefit from a geriatric assessment: a systematic review[J]. JAMA Oncol, 2021,7:616-627. doi:10.1001/jamaoncol.2020.6736. |
| [20] | Almatrafi A, Gabe R, Beeken RJ,et al.Impact of frailty and comorbidity on initial response to lung cancer screening invitation and low-dose CT screening uptake: Findings from the Yorkshire Lung Screening Trial[J].J Med Screen, 2025:9691413251315087. doi:10.1177/09691413251315087. Online ahead of print. |
| [21] | Hinojo C, Cantos B, Antolin S,et al.Identification and management of medical comorbidities in patients with HR+/HER2- metastatic breast cancer treated with CDK4/6 inhibitors: literature review and recommendations from experts in spain opinion[J].Clin Breast Cancer, 2024:S1526-8209(24)00367-7. doi:10.1016/j.clbc.2024.12.016. Online ahead of print. |
| [22] | McDonagh J, Lindley RI, Byth K,et al. Frailty in older adults admitted to hospital: outcomes from the Western Sydney Clinical Frailty Registry[J].BMC Geriatr, 2025,25:78. doi:10.1186/s12877-025-05715-0. |
| [23] | Cai PP, Gu LL,Wang X,et al.A single-center prospective cohort study assessing preoperative gait speed assessment as a prognostic tool for morbidity and mortality in frail elderly patients undergoing abdominal surgery[J].Braz J Med Biol Res, 2025,58:e14103. doi:10.1590/1414-431X2024e14103. eCollection 2025. |
| [24] | Tariq A, Alireza S,Zadeh M,et,al.Relationship between multiple morbidities and performance on the Timed Up and Go test in elderly patients: a cross-sectional study[J].BMJ Open,2025,15:e088950. doi:10.1136/bmjopen-2024-088950. |
| [25] | Schmidt AM,Kristensen HN,Melgaard D,et al. Development of a screening intervention for dysphagia in hospitalised geriatric patients.[J]. Dysphagia, 2025,30. doi:10.1007/s00455-025-10803-9. Online ahead of print. |
| [26] | Yuan GY, Ye GX, Hu JG,et al.Nomogram to screen older adult patients attending the radiology department for sarcopenia[J].BMC Geriatr, 2025,25:69. doi:10.1186/s12877-025-05730-1. |
| [27] | Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus updated on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020,21:300-307.e2. doi:10.1016/j.jamda.2019.12.012. |
| [28] | Bruijnen CP,van Harten-Krouwel DG,Koldenhof JJ,et al. Predictive value of each geriatric assessment domain for older patients with cancer: a systematic review[J]. J Geriatr Oncol, 2019,10:859-873. doi:10.1016/j.jgo.2019.02.010. |
| [29] | Stypulkowski K, Rodrigues J, Cieri F,et al.Comparison of the beck anxiety inventory and the geriatric anxiety scale in an older adult neurology clinic sample[J].Arch Clin Neuropsychol, 2025,4:acaf006. doi:10.1093/arclin/acaf006. Online ahead of print. |
| [30] | Park YS,Yoo K,KimHJ,et al.Association between sarcopenia components and depressed mood varies by sex among community-dwelling older adults from the Korean Frailty and Aging Cohort Study[J].Sci Rep,2025,15:3987.doi:10.1038/s41598-025-88437-y. |
| [31] | Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer[J]. J Clin Oncol, 2008, 26:2925-2926. |
| [32] | Mohamed MR, Rich DQ, Seplaki C, et al. Primary treatment modification and treatment tolerability among older chemotherapy recipients with advanced cancer[J].JAMA Netw Open,2024,7:e2356106.doi:10.1001/jamanetworkopen.2023.56106. |
| [33] | Tucci A, Ferrari S, Bottelli C et al. A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy[J].Cancer, 2009,115:4547-4553. doi:10.1002/cncr.24490. |
| [34] | Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study[J]. J Clin Oncol, 2011,29:3457-3463. doi:10.1200/JCO.2011.34.7625. |
| [35] | Hurria A, Mohile S, Gajra A, et al. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer[J]. J Clin Oncol,2016,34:2366-2371. doi:10.1200/JCO.2015.65.4327. |
| [36] | Extermann M, Boler I, Reich RR, et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score[J]. Cancer, 2012,118:3377-3386. doi:10.1002/cncr.26646. |
| [37] | Ortland I, Ott MM, Kowar M, et al. Comparing the performance of the CARG and the CRASH score for predicting toxicity in older patients with cancer[J]. J Geriatr Oncol, 2020,11:997-1005. doi:10.1016/j.jgo.2019.12.016. |
| [38] | Pang A, Low JL, Ng A, et al. Use of the cancer and aging research group predictive model for chemotherapy-related toxic effects in a multiethnic, older adult Asian population[J]. JAMA Netw Open, 2022,5:e2237196. doi:10.1001/jamanetworkopen.2022.37196. |
| [1] | DONG Zeyao, LIN Shuyu, DAI Li. Autophagy inhibitor Spautin-1 increases apoptosis rate in human pancreatic cancer cell line PaTu 8988t [J]. Basic & Clinical Medicine, 2026, 46(7): 932-938. |
| [2] | WU Yani, DAI Jiayin, YANG Zhenli, HOU Yuhong, BIAN Xiaocui, LIU Yuqin. Establishment of KRAS G12C-mutant pancreatic cancer cell strains with stable Cas9 expression and differential sensitivity to targeted KRAS inhibitors [J]. Basic & Clinical Medicine, 2026, 46(7): 965-974. |
| [3] | ZHEN Hongnan, WANG Fang, XIAO Jianing, JIANG Fei, ZHANG Yuan, SHEN Jing. Association between baseline nutritional status and chronic radiotherapy-induced adverse effects [J]. Basic & Clinical Medicine, 2026, 46(7): 998-1003. |
| [4] | CHEN Weixin. Analysis of the immune characteristics of peripheral blood lymphocyte subsets in patients with early and advanced non-small cell lung cancer [J]. Basic & Clinical Medicine, 2026, 46(6): 823-829. |
| [5] | ZHANG Shuai, WANG Tengqi, TIAN Yongjing, PANG Jian, SUN Haibin, LEI Xinwen. KRT15 regulates the immune microenvironment and suppresses malignant phenotypes in gastric cancer [J]. Basic & Clinical Medicine, 2026, 46(5): 658-665. |
| [6] | YAN Luyu, WANG Chao, FENG Shuo. FAM83H-AS1 promotes epithelial-mesenchymal transition and angiogenesis in the endometrial cancer cell line Ishikawa [J]. Basic & Clinical Medicine, 2026, 46(4): 517-523. |
| [7] | LIU Pengpeng, SUN Zhao, QIU Wei, TANG Hui, ZHU Wenjia, WANG Wenhui, WANG Yingyi. Impact of local radiotherapy on tyrosine kinase inhibitor treatment in non-small cell lung cancer with oligo-residual disease [J]. Basic & Clinical Medicine, 2026, 46(4): 491-497. |
| [8] | ZHANG Zhen, YANG Lianren, HU Junkun, ZHANG Wei, LIANG Wei. Value of serum D-dimer in evaluating chemotherapy effect and prognosis in patients with non-small cell lung cancer [J]. Basic & Clinical Medicine, 2026, 46(3): 417-420. |
| [9] | ZHAN Sen, LIU Yujie, LI Tiankang, ZHANG Chong, REN Zeqiang, ZHANG Yi. Elevated expression of circGAPVD1 in plasma-derived exosomes is correlated with disease progression in colorectal cancer patients [J]. Basic & Clinical Medicine, 2026, 46(3): 374-380. |
| [10] | LONG Fangwen, ZHENG Xia, QIAN Jun, ZHANG Yifen. Research progress on the mechanisms of omental metastasis in gastric cancer [J]. Basic & Clinical Medicine, 2026, 46(2): 282-287. |
| [11] | ZHANG Tingting, XU Yiping, SHANG Tao. LINC01123 promotes cell proliferation of colorectal cancer in vivo by regulating miR-625-5p/LASP1 signaling axis [J]. Basic & Clinical Medicine, 2026, 46(2): 186-192. |
| [12] | LI Zhitao, BU Xuefeng, ZHANG Yongjun, MENG Nana, XIA Leizhou. Farnesoid X receptor suppresses pancreatic cancer cell proliferation through negative regulation of matrix metalloproteinase 7 [J]. Basic & Clinical Medicine, 2026, 46(2): 250-255. |
| [13] | LU Wei, WANG Yanmin, LIU Bingchen, TAO Xin, WANG Shipeng, CAO Qiuye. Berberine enhances the chemotherapy sensitivity of prostate cancer cell line 22RV1 to docetaxel [J]. Basic & Clinical Medicine, 2026, 46(1): 39-45. |
| [14] | LI Binfeng, LYU Fayou, YI Huijun, LYU Lyu. Advances in the mechanism of action of the ring finger proteins family in breast cancer [J]. Basic & Clinical Medicine, 2026, 46(1): 124-128. |
| [15] | WANG Yangyang, LIU Yang, ZHAO Han, WANG Wei. Current applications and implications of Comprehensive Geriatric Assessment in elderly cancer patients [J]. Basic & Clinical Medicine, 2025, 45(9): 1132-1138. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||