Abstract: It is found in recent years that ferroptosis is a kind of regulatory cell death induced by iron dependent lipid peroxidation and reactive oxygen species (ROS) . It is involved in many clinical diseases such as tumor, nervous system illness and ischemia-reperfusion injury. Huntington's disease (HD) is an important neurodegenerative disorder. This article Huntington's disease. This article describes the definition and characteristics of ferroptosis and its different pathways. At the same time, since ferroptosis is involved in the development of HD, it also focuses on the HD treatment for ferroptosis .

Key words: ferroptosis, lipid peroxidation, ROS, Huntington’s disease