Abstract: The pyroptosis is a new model of cell death . This pattern not only activates caspase-1/4/5/11 on GSDMD by relying on pattern recognition receptors to recognize endogenous dangerous signals and the role of pathogenic microorganisms and their products in stimulating inflammatory bodies；but also it makes GSDMD-NT transfer to the cell membrane to form pores that allows water molecules and other substances to enter the cell and cause cell swelling and cleavage. However, in pyroptosis，the role of GSDMD and its role in diseases and tumours remains a mystery.So,the review is to highlight the role of GSDMD that it can lead to pyroptosis in diseases and tumours.

Key words: Pyroptosis, GsderminD, Cell swelling , Caspase-1/4/5/11