Abstract: Histones can be released into the extracellular space，and lead to lethal sepsis , ischemia reperfusion injury, trauma, pancreatitis, coagulation and thrombosis. In addition, the increase of serum histone is related to the pathological and pathophysiological process of autoimmune diseases, nervous system diseases and tumors. Therefore, extracellular histone can be used as biomarkers and therapeutic targets for a variety of human diseases.

Key words: Histone, nucleosome, antibody, inflammation