Abstract: Stanniocalcin-1(STC1) was initially discovered as a glycoprotein hormone keeping the homeostasis of calcium and phosphate. In addition, STC1 also plays an important role in cancer. STC1 promotes proliferation, angiogenesis, invasion and metastasis and inhibits apoptosis and hypoxia. Emerging evidences show that STC1 may be the next new biomarker, which will be useful for the diagnosis, treatment and prognosis of cancer.

Key words: stanniocalcin-1, cancer, apoptosis, hypoxia, metastasis and invasion